My current research focuses on integrating phylogenetics and horizontal gene transfer (HGT) with studies of microbial evolution and planetary history. Areas of focus include:
-HGT based calibration of molecular clock models of microbial evolution;
-The role of partial HGT on phylogenetic inference;
-The impact of protein structure on partial HGT and evolutionary models;
-Ancestral sequence reconstruction of ancient protein families;
-The biogeochemical impact of HGT and microbial metabolism evolution;
-Using HGT events to identify novel antibiotic drug targets for protozoan diseases.